Which is better cyanocobalamin or hydroxocobalamin

However, some research suggests that differences in bioavailability between the two forms may be insignificant and that absorption could be influenced by factors such as age and genetics 7 , 8. Unfortunately, recent research directly comparing these two forms of vitamin B12 is limited. Additional studies are needed to measure the absorption and retention of methylcobalamin versus cyanocobalamin in healthy adults. Research shows that cyanocobalamin may be absorbed better in your body, while methylcobalamin likely has a higher retention rate.

Other studies have found that the differences in absorption and retention are minimal. When you ingest cyanocobalamin, it can be converted to both of the active forms of vitamin B12, methylcobalamin and adenosylcobalamin.

Deficiencies in both forms of vitamin B12 can increase your risk of neurological issues and adverse side effects Some researchers recommended treating vitamin B12 deficiencies with either cyanocobalamin or a combination of methylcobalamin and adenosylcobalamin due to distinct properties of these latter two forms 9. While they differ in some aspects, both cyanocobalamin and methylcobalamin can be converted to other forms of cobalamin within the body. Although distinct differences exist between methylcobalamin and cyanocobalamin, both have beneficial effects on health and can prevent B12 deficiencies In fact, one study found that treating seven Bdeficient people with oral methylcobalamin normalized vitamin B12 levels in their blood within just 2 months Similarly, another study showed that taking cyanocobalamin capsules for 3 months also increased vitamin B12 levels in 10 people with pernicious anemia , a condition caused by impaired B12 absorption One review of seven studies showed that both methylcobalamin and a B-complex containing cyanocobalamin were effective in reducing symptoms of diabetic neuropathy, a complication of diabetes that leads to nerve damage Additionally, several animal studies have found that each form could have neuroprotective effects and may be beneficial in treating conditions that affect your nervous system 16 , Both methylcobalamin and cyanocobalamin can treat vitamin B12 deficiency.

Animal and human studies have found that they could reduce symptoms of diabetic neuropathy and may have neuroprotective effects as well. If you think you may have a vitamin B12 deficiency, talk to your doctor to determine the best course of treatment. Cyanocobalamin is a synthetic form of vitamin B12 that can be converted to the natural forms methylcobalamin and adenosylcobalamin. Both can prevent B12 deficiency, but methylcobalamin should be combined with adenosylcobalamin for best results.

Check your clinic is fully licenced to administer this treatment before progressing. IV Boost is licenced to give Vitamin B12 injections or IV drips and we will only do this following a face-to-face consultation which establishes if this is both necessary and suitable.

To organise a consultation regarding our B12 shots or IV drips, contact our team today on But, for those in the know, B vitamins are the IV Vitamin Drips is becoming increasingly popular as more and more people experience the benefits of replenishing nutrients for optimal health.

As one of the original su Vitamin B12 is essential to our wellbeing. Adenosylcobalamin Adenosylcobalamin is also a naturally occurring, co-enzyme form of Vitamin B Hydroxocobalamin Hydroxocobalamin is naturally produced by bacteria in the digestive tract when food sources are broken down.

Cyanocobalamin Cyanocobalamin is an artificial form of Vitamin B12 which the body converts into the active forms of Methylcobalamin and Adenosylcobalamin, ready for use. Methylcobalamin vs Cyanocobalamin People often ask which is better — the naturally occurring Methylcobalamin or the synthetic Cyanocobalamin? In my practice I also use methylcobalamin when I do Prolozone injections into joints and into subcutaneously under the skin. This is also a better choice for smokers who are unable to convert cyanocobalamin into methylcobalamin.

If given intramuscularly it is mixed the local anesthetic procaine. Hydroxocobalamin is retained longer in the body and can be dosed less frequently. An additional application of hydroxocobalamin is that it can be used for patients with cyanide poisoning as it binds cyanide and allows for elimination through the kidneys.